U.K. scientists say they have developed a new technique capable of rewinding the aging of skin cells by about 30 years.
Published in the journal eLife, researchers from the Babraham Institute's epigenetics research program say in a news release that they partly restored the function of older cells, without losing their specialized function.
These partially rejuvenated cells also showed signs of behaving more like youthful cells.
While still in its early stages, they say the research, if replicated in other cell types, could have implications for regenerative medicine and create cells that are better at healing wounds.
"Our results represent a big step forward in our understanding of cell reprogramming," postdoctoral researcher Diljeet Gill, who conducted the work as a PhD student, said in a statement.
"We have proved that cells can be rejuvenated without losing their function and that rejuvenation looks to restore some function to old cells. The fact that we also saw a reverse of aging indicators in genes associated with diseases is particularly promising for the future of this work."
The researchers say one of the most important tools in regenerative biology is the ability to create induced stem cells, which involves erasing some of the markers that make a cell specialized.
Rather than entirely erasing the identity of cells in their study, however, the researchers used a new method called maturation phase transient reprogramming, based on a Nobel Prize-winning technique to make stem cells.
The new method halts reprogramming partway through, allowing the scientists to make the cells biologically younger while still allowing them to regain their specialized function.
In this case, further analysis showed the cells regained markers characteristic of skin cells or fibroblasts and produced more collagen proteins, used to provide structure to tissues and help heal wounds, than cells that did not undergo the reprogramming process.
The scientists then tested the rejuvenated cells by creating an artificial cut in a layer of cells in a dish.
The experiment found that treated fibroblasts moved into the gap faster than older cells.
Not only did the reprogrammed cells "time jump" by 30 years, the researchers say the method also had an effect on other genes linked to age-related diseases such as Alzheimer's and cataracts.
"This work has very exciting implications," said Prof. Wolf Reik, who led the research.
"Eventually, we may be able to identify genes that rejuvenate without reprogramming, and specifically target those to reduce the effects of aging. This approach holds promise for valuable discoveries that could open up an amazing therapeutic horizon."
David Lavery, a former Canadian Forces soldier who helped approximately 100 people flee Afghanistan during the fall of Kabul, has been 'picked up' by the Taliban this week, according to multiple sources who spoke to CTV National News on the condition of anonymity.
The Canada Revenue Agency will be eliminating approximately 600 temporary and contract employees across the country by mid-December.
A 47-year-old Terrebonne man has been charged following a case of road rage in broad daylight last summer on the Ile-aux-Tourtes bridge.
Alberta Premier Danielle Smith will be heading to Washington, D.C., for Donald Trump's presidential inauguration.
Some travellers who checked baggage on certain WestJet flights between 2014 and 2019 may now claim their share of a class-action settlement approved by the British Columbia Supreme Court last month and valued at $12.5 million.
U.S. President-elect Donald Trump on Friday named Karoline Leavitt, his campaign press secretary, to serve as his White House press secretary.
YouTuber-turned-boxer Jake Paul had to wait an extra four months for his high-profile match with 58-year-old former heavyweight champion Mike Tyson, but fight night has arrived.
Iran successfully sought a meeting with Elon Musk, according to a U.S. official, one in a series of steps that appeared aimed at easing tensions with President-elect Donald Trump.
The criminal charges against former Ontario legislator Randy Hillier related to his participation in the 'Freedom Convoy' protest have been stayed after a judge ruled his case had taken too long.
A 47-year-old Terrebonne man has been charged following a case of road rage in broad daylight last summer on the Ile-aux-Tourtes bridge.
Regina voters in two wards made history Wednesday night, electing two women of colour to serve on council for the first time in the city's history.
The "Roaring Lion" returned to the walls of Ottawa's Fairmont Château Laurier, nearly three years after the historic portrait of Sir Winston Churchill was stolen.
A former elementary school principal in Waterloo, Ont. has pleaded guilty to charges that include luring and transmitting sexually explicit material to someone believed to be under the age of 16.
Alberta Premier Danielle Smith will be heading to Washington, D.C., for Donald Trump's presidential inauguration.
Javier Milei's Argentina cast the sole vote against a non-binding UN resolution that denounced violence against women and girls.
A federal judge in Texas has blocked a new rule from the Biden administration that would have expanded access to overtime pay to millions more salaried workers across the U.S.
The United Nations and other international organizations are bracing for four more years of Donald Trump.
A federal appeals court in New Orleans on Friday temporarily limited the scope of a ruling that Louisiana's law requiring public schools to post the Ten Commandments in all classrooms next year is unconstitutional.
U.S. President-elect Donald Trump on Friday named Karoline Leavitt, his campaign press secretary, to serve as his White House press secretary.
Iran successfully sought a meeting with Elon Musk, according to a U.S. official, one in a series of steps that appeared aimed at easing tensions with President-elect Donald Trump.
Canada's Employment Minister Randy Boissonnault is apologizing after shifting claims about his Indigenous identity came under scrutiny.
Top officials in both Canada and the United States are pushing for the need to finalize the Columbia River Treaty to manage water flowing between the two countries before the administration change in America.
Canada's parliamentary budget officer says the federal government is overestimating the impact its new immigration plan will have on the country's housing shortage.
The two biggest children’s hospitals in Montreal - the CHU Sainte-Justine and Montreal Children's Hospital - are asking parents to avoid bringing their children to the emergency room if possible due to a surge in patients.
Despite decades of calls for more attention to patient safety in hospitals, people undergoing surgery still have high rates of complications and medical errors, a new study finds.
U.S. President Donald Trump's pick of Robert F. Kennedy Jr. for secretary of the Department of Health and Human Services "is an extraordinarily bad choice for the health of the American people," warns the dean of the Brown University School of Public Health.
While it remains small compared to established online spaces such as X, Bluesky has emerged as an alternative for those looking for a different mood, lighter and friendlier and less influenced by Musk.
A species of marine worm that scientists lost sight of for almost 70 years has finally resurfaced, thanks to some eagle-eyed sleuthing and a seahorse less than an inch long. When researchers analyzed images of tiny seahorses taken by scuba divers, they found evidence of photobombing worms in the hundreds, living alongside the seahorses in coral colonies from Japan to Australia.
The moon has some new stories to tell. Scientists have published the first detailed analyses of the historic cache of lunar soil and rock that China retrieved from the far side of the moon this year.
Plenty of people loved Hugh Grant's character in the 1999 rom-com 'Notting Hill,' but Grant is not one of them. He talked about playing William Thacker, opposite Julia Roberts as Anna Scott, during a conversation for Vanity Fair’s 'Scene Selection.'
A Nova Scotia couple fulfilled their wildest dreams Thursday night when they got engaged at Taylor Swift’s Eras Tour in Toronto.
Toronto's Taylor Swift era is in full swing and fans are making the whole city shimmer with their outfits.
Counseling and health services firm Equinox on Friday disclosed a data breach involving the personal health information of some current and former clients, as well as staff and has notified the individuals likely to have been affected.
The CRTC is looking at how to redefine Canadian content, launching a new consultation with plans to hold a public hearing in the spring.
Some travellers who checked baggage on certain WestJet flights between 2014 and 2019 may now claim their share of a class-action settlement approved by the British Columbia Supreme Court last month and valued at $12.5 million.
The Timmins rock band Miners and Sons have made history. The group performed a rock concert in the world’s deepest base metal mine below sea level, breaking a Guinness World Record.
Bored of the usual lump of cheddar? You could do a lot worse than swapping it out with a piece of Queijo de Ovelha Amanteigado, a soft, raw ewes’ milk cheese that was on Friday named 2024’s winner at an annual contest to find the world’s best cheese.
A Calgary man has won $5 million from a Lotto 6-49 ticket, but it's not his first lottery win.
Like Wonka’s famous golden ticket, the Pittsburgh Pirates are offering a scrumdiddlyumptious prize in exchange for a rare, one-of-a-kind baseball card of their star pitcher Paul Skenes.
YouTuber-turned-boxer Jake Paul had to wait an extra four months for his high-profile match with 58-year-old former heavyweight champion Mike Tyson, but fight night has arrived.
Running back Brady Oliveira of the Winnipeg Blue Bombers is the CFLs outstanding player.
In part two of a three-part series into how thieves are able to drive off with modern vehicles so easily, CTV W5 correspondent Jon Woodward uses a device flagged by police to easily clone a car key.
When a Tesla crashed on Lakeshore Boulevard in Toronto last month, the first people on scene knew there were occupants inside but couldn't immediately get them out.
Almost four out of five Canadian drivers switch to winter tires when the weather calls for them, according to a new survey.
When George Arcioni began renovating his kitchen last summer, he didn’t expect to find a stack of letters hidden in the wall behind his oven.
A Nova Scotia couple fulfilled their wildest dreams Thursday night when they got engaged at Taylor Swift’s Eras Tour in Toronto.
Some Calgary residents caught what appeared to be a meteor streaking across the sky early on Wednesday morning.
Four years ago, Phill Hebb started up 'Phil’s Unique Birdhouses' and since then, they’ve made their way all across Canada and into the United States.
A New Brunswick fashion designer recently won the top prize at a national event for a dress she made using an unconventional material.
Dr. Ronald Weiss, who performed nearly 60,000 vasectomies on Ottawa men, establishing him as the "Wayne Gretzky" of the procedure, has died.
A congestion crisis, a traffic nightmare, or unrelenting gridlock -- whatever you call it, most agree that Toronto has a congestion problem. To alleviate some of the gridlock, the Ontario government has announced it plans to remove bike lanes from three major roadways.
For the second year in a row, the ‘Gift-a-Family’ campaign is hoping to make the holidays happier for children and families in need throughout Barrie.
Some of the most prolific photographers behind CTV Skywatch Pics of the Day use the medium for fun, therapy, and connection.
Video circulating on social media shows several security guards at a Surrey, B.C., mall physically pinning a teenage girl to the ground as she cries out in distress.
A group of Vancouver residents are speaking out against a proposed 18-storey high-rise development for W 14th Street and Yukon.
A family from B.C.’s Lower Mainland is speaking out after a hacker managed to steal their four tickets to Taylor Swift’s Eras Tour, leaving two young fans temporarily heartbroken.
Peel police are searching for a Toronto man who allegedly sold fake sporting and concert tickets to a victim, which resulted in a loss of over $38,000.
The FBI has released a new image of Ryan James Wedding, the Canadian ex-Olympian allegedly behind a deadly international drug ring.
A Toronto couple bought two tickets to one of Taylor Swift's tour stops in the city, but unfortunately their love story didn't last and now they're fighting for who gets the seats.
Alberta RCMP have charged a fifth person in the death of Calgarian Tara Miller.
The city released preliminary findings of an investigation into the failure of the Bearspaw South feeder main late Friday afternoon suggesting that there were a number of factors behind its failure.
Alberta Premier Danielle Smith will be heading to Washington, D.C., for Donald Trump's presidential inauguration.
An adult has been taken to hospital in life-threatening condition following a single-vehicle crash on Highway 417 in Ottawa Friday afternoon, paramedics say.
We're learning more details about the city's plan to build two Sprung Structures to house asylum seekers and refugees, including what exactly the structures are, and how they will be used.
Business owners in Ottawa are raising concerns amid Canada Post strike ahead of the holiday season.
A 47-year-old Terrebonne man has been charged following a case of road rage in broad daylight last summer on the Ile-aux-Tourtes bridge.
Montreal police (SPVM) have confirmed that a 76-year-old man died after a collision with an SUV in Montreal’s Rivière-des-Prairies neighbourhood.
Québec solidaire (QS) delegates are set to officially appoint Ruba Ghazal as the party’s female co-spokesperson during a special virtual congress this weekend.
An Edmonton woman was charged in the drowning of a five-year-old girl last month.
A couple's wedding day is something they'll remember forever, but for some recently married in Edmonton it's memorable for the wrong reasons.
RCMP are warning Fort McMurray residents about a wanted man in the community.
All three Maritime provinces are working on alternatives to ensure residents receive vital mail, like government cheques, after Canada Post workers hit the picket lines Friday morning.
The RCMP in Nova Scotia is seeking information about a shooting in North Preston, N.S.
On Friday, the Art Gallery of Nova Scotia (AGNS) reported on Facebook that Tom Forrestall had passed away.
A Winnipeg pawn shop owner is speaking out after a violent robbery at his McPhillips Street location.
When George Arcioni began renovating his kitchen last summer, he didn’t expect to find a stack of letters hidden in the wall behind his oven.
A hectic blur. That is how the opening day of Canada Life Centre—originally MTS Centre—is remembered by many who were involved in bringing the arena to downtown Winnipeg 20 years ago.
Despite the cancellation of a planned flag raising, a group of demonstrators gathered at Regina city hall Friday to mark Palestine’s Independence Day.
A Saskatchewan man is facing a child pornography charge following investigation by the provincial Internet Child Exploitation (ICE) Unit.
Regina voters in two wards made history Wednesday night, electing two women of colour to serve on council for the first time in the city's history.
A former elementary school principal in Waterloo, Ont. has pleaded guilty to charges that include luring and transmitting sexually explicit material to someone believed to be under the age of 16.
A woman who was hit by a vehicle in Cambridge, Ont. is speaking out about the scary experience.
Canadian Union of Postal Workers said approximately 55,000 workers are striking, claiming little progress has been made in the bargaining process.
A Saskatoon rubber manufacturer is taking the province to court, claiming millions of dollars in damages for breach of a contract as part of a dispute that's lasted more than two years.
One of two boys involved in an unintentional fatal shooting of their 12-year-friend sentenced on Friday.
Saskatoon firefighters responded to a garage fire on the 100 block of Avenue U South Thursday night.
Newly released documents show the Royal Canadian Mounted Police collected wreckage after an unidentified object was shot down over Lake Huron in February of last year.
A 72-year-old teacher from Blind River has been charged with multiple counts of sexual assault involving two victims under the age of 16.
The Timmins rock band Miners and Sons have made history. The group performed a rock concert in the world’s deepest base metal mine below sea level, breaking a Guinness World Record.
Within hours of charges being dropped in a London court on Tuesday, Loubani attended Fragiskatos’ office once more, and repeated the incident – expressing no concern of being charged.
The Ausable Bayfield Conservation Authority (ABCA) says that work undertaken without a permit has cost some beach front property owners in Grand Bend a pretty penny.
A couple in the Middlesex County village of Kerwood, west of London, says their neighbourhood has so many cats that it’s negatively impacting their quality of life - they say that their township, Adelaide Metcalfe, is allowing the problem to get worse.
Officials held a groundbreaking ceremony Friday afternoon to celebrate the first phase of the Sky Towers development on Grove Street West in Barrie, which will add more than 500 new units to the City’s housing market.
One person was left with signs of hypothermia after being rescued from Kempenfelt Bay in the early hours of the morning.
Chris Forrester’s mother took the witness stand on Friday in the second-degree murder trial of a man accused of killing her son three years ago.
A memorial stone and oak trees have been protected from excavation along the corridor where the two-lane highway is expanding to four in Kingsville.
There was no shortage of support for Canada Post workers while passing by strike lines in Windsor and Tecumseh.
The federal government has expanded a security program that aims to fight hate crime.
Some travellers who checked baggage on certain WestJet flights between 2014 and 2019 may now claim their share of a class-action settlement approved by the British Columbia Supreme Court last month and valued at $12.5 million.
Intense flooding that hammered British Columbia's coast last month has led to more than $110 million in insured damage claims.
A Nanaimo nurse has agreed to a seven-day suspension for accessing patient records without authorization.
British Columbia's independent police watchdog has cleared officers of wrongdoing in a crash where three people were killed south of Kamloops in July of last year.
A B.C. woman who stole more than $14,000 in volunteer-raised funds that were supposed to be spent on school supplies and programs – including hot meals for vulnerable kids – won't spend any time in jail.
The emergency department at South Okanagan General Hospital in Oliver, B.C., will be closed for 31 hours this weekend, the second such closure in a week and the third since the start of November.
Early Friday morning, the union representing Canada Post workers officially went on strike. The strike will have a wide-reaching impact on many Canadians, and it comes at a difficult time for charities.
A back-and-forth question between Alberta Premier Danielle Smith and Alberta NDP Leader Naheed Nenshi when it comes to calling a Lethbridge-West byelection has no distinct answer nearly five months later.
Two hundred students from across southern Alberta set sail at the University of Lethbridge Thursday, in cardboard boats.
A Sault Ste. Marie program that gives people on social housing the opportunity to purchase a newly renovated home has just changed the lives of another local family.
About 700 Canada Post workers are walking the picket lines in communities across northeastern Ontario.
After receiving reports of a dangerous and erratic driver, police in Sault Ste. Marie charged the driver of a vehicle on Highway 17 this week.
Newfoundland and Labrador's return on investment for sponsoring a professional English soccer team was not quite as rosy as previously claimed.
Police in Newfoundland say a man was electrocuted Saturday by a downed power wire about 10 kilometres north of St. John's, N.L.
On Thursday morning, Dave Penny officially ended a suggested hundred-day isolation period that followed his diagnosis and stem cell treatment for non-Hodgkin's Lymphoma. On Thursday night, Penny returned to a stage at a downtown St. John's bar, regaling a small crowd with songs and stories with a distinctive Newfoundland flair.
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