The first participants have been vaccinated in a Phase 1 clinical trial of an experimental HIV vaccine that utilizes Moderna's mRNA technology, the company announced last week.
The trial, titled IAVI G002, is being conducted in partnership IAVI, a nonprofit scientific research organization. It is testing a vaccine that delivers HIV-specific antigens to the body with the goal of inducing an immune response. These antigens were initially developed by researchers at IAVI and Scripps Research, led by Dr. William Schief.
In a "proof-of-concept" trial last year, the research team found the HIV antigens produced the desired immune response in 97% of participants. The current trial builds on the previous one by testing the primary version of the vaccine and also a booster version, and by employing Moderna's mRNA technology, which was previously used to create a successful COVID-19 vaccine.
"We are tremendously excited to be advancing this new direction in HIV vaccine design with Moderna's mRNA platform. The search for an HIV vaccine has been long and challenging, and having new tools in terms of immunogens and platforms could be the key to making rapid progress toward an urgently needed, effective HIV vaccine," Mark Feinberg, IAVI's president and CEO, said in a news release from Moderna.
The new trial, funded in part by the Bill & Melinda Gates Foundation, will follow 56 HIV-negative adult participants, with the goal of studying both the safety and efficacy of the vaccine. Forty-eight of the volunteers will receive at least one dose of the primary vaccine, 32 of which will also receive the booster. The remaining eight will receive the booster vaccine alone.
The trial includes participants from four locations: George Washington University School of Medicine, Hope Clinic of Emory Vaccine Center, Fred Hutchinson Cancer Research Center, and the University of Texas Health Science Center at San Antonio.
Canadians will soon receive a temporary tax break on several items, along with a one-time $250 rebate, Prime Minister Justin Trudeau announced Thursday.
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U.S. president-elect Donald Trump on Thursday named Pam Bondi, the former attorney general of Florida, to be U.S. attorney general just hours after his other choice, Matt Gaetz, withdrew his name from consideration.
A rare one-of-a-kind pure gold coin from the Royal Canadian Mint has sold for more than $1.5 million. The 99.99 per cent pure gold coin, named 'The Dance Screen (The Scream Too),' weighs a whopping 10 kilograms and surpassed the previous record for a coin offered at an auction in Canada.
Russian President Vladimir Putin announced Thursday that Moscow has tested a new intermediate-range missile in a strike on Ukraine, and he warned that it could use the weapon against countries that have allowed Kyiv to use their missiles to strike Russia.
Canadians won't have to pay GST on a selection of items this holiday season, the prime minister vowed on Thursday.
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Taylor Swift is officially back in Toronto for round two. The popstar princess's motorcade was seen driving along the Gardiner Expressway on Thursday afternoon, making its way to the downtown core ahead of night four of ‘The Eras Tour’ at the Rogers Centre.
Approximately 85,000 new passports are being held back by Service Canada, which stopped mailing them out a week before the nationwide Canada Post strike.
An investigation into how the Canadian Coast Guard responded to a Nova Scotia vessel in distress two years ago raises questions about why one fisherman died after a towing operation went awry.
Calgary police are seeking information in relation to a Tuesday fire in Hillhurst they believe was deliberately set and notes left in the area demanding Bitcoin.
Municipal officials are considering an end to water fluoridation on the island of Montreal in a move spurred by a petition from a resident who claims he has the support of Robert F. Kennedy Jr.
Approximately 85,000 new passports are being held back by Service Canada, which stopped mailing them out a week before the nationwide Canada Post strike.
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An Alabama inmate convicted in the 1994 killing of a female hitchhiker cursed at the prison warden and made obscene gestures with his hands shortly before he was put to death Thursday evening in the nation's third execution using nitrogen gas.
North Korean leader Kim Jong Un said his past negotiations with the United States only confirmed Washington’s "unchangeable" hostility toward Pyongyang and described his nuclear buildup as the only way to counter external threats, state media said Friday.
Mexico's president acknowledged Thursday that Canada is concerned about reports of a Chinese company's plan to build an auto plant in Mexico, but she said it does not currently exist.
Brazil's federal police said Thursday they indicted former President Jair Bolsonaro and 36 other people on charges of attempting a coup to keep him in office after his electoral defeat in the 2022 elections.
A recent lawsuit alleges Linda McMahon, who U.S. President-elect Donald Trump tapped to lead the Department of Education, knowingly enabled the sexual exploitation of children by a World Wrestling Entertainment (WWE) employee as early as the 1980s — allegations she denies.
More than 60 years after President John F. Kennedy was assassinated, conspiracy theories still swirl and any new glimpse into the fateful day of Nov. 22, 1963, in Dallas continues to fascinate.
Canada's consul general in New York doubled-down Thursday on his past claim that he exerted no influence on the decision of Global Affairs Canada to buy a $9 million condo in Manhattan.
Prime Minister Justin Trudeau said Canada will 'abide' by an International Criminal Court (ICC) arrest warrant for Israeli Prime Minister Benjamin Netanyahu.
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A Dallas anesthesiologist was sentenced Wednesday to 190 years in prison for injecting a nerve-blocking agent and other drugs into bags of intravenous fluid at a surgical center where he worked, leading to the death of a coworker and causing cardiac emergencies for several patients.
The Canadian Space Agency (CSA) is inviting Canadians to choose the name of the first Canadian Lunar Rover.
Astronomers have captured the first close-up image of a star beyond our galaxy, taken during a dramatic moment near the end of the star’s life. In it, the 'behemoth' star appears to puff out gas and dust, a critical final step before exploding in a supernova.
A rare kind of fruit fly has been caught by U.S. Customs and Border Protection (CBP) agriculture specialists at Detroit Metro Airport.
Pamela Hayden, the longtime voice actor behind Milhouse Van Houten — Bart Simpson's very uncool friend — is stepping away after 35 years of whining.
Everybody who lived in Edmonton in the 1980s knew it was famous for two things: the mall and the Oilers.
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FunGuyz, which calls itself the biggest magic mushroom dispensary in Canada, says it's shutting down all 30 of its Ontario locations.
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Irving Tissue said it needs to expand in Macon because the mill is currently selling all the bath tissue and paper towels it can make
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Sandra Kroek and her grandson Remington spent 200 hours painting a massive Star Wars mural together.
CTVNews.ca wants to hear from digital nomads who have taken up location-independent jobs and can work from anywhere with an internet connection.
Alex Ovechkin has a broken left fibula and is expected to be out four to six weeks, an injury that pauses the Washington Capitals superstar captain’s pursuit of Wayne Gretzky’s NHL career goals record.
Sea Bears centre Chad Posthumus has died at age 33.
Shohei Ohtani won his third Most Valuable Player Award and first in the National League, and Aaron Judge earned his second American League honour on Thursday.
Northvolt AB has filed for bankruptcy protection in the United States, but said the move will not jeopardize the manufacturer's planned electric vehicle battery plant in Quebec — though hundreds of millions of taxpayer dollars invested in the parent company could be lost.
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After driving near the water that winter day, Brian Lavery thought he saw a dog splashing in the waves – then realized it was way too cold for that.
Toronto radio and podcast host Jax Irwin has recently gone viral for videos of her cute -- and at times confusing -- phone conversations.
Two young women from New Brunswick have won one of the most prestigious and sought-after academic honours in the world.
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A Nova Scotia couple fulfilled their wildest dreams Thursday night when they got engaged at Taylor Swift’s Eras Tour in Toronto.
Some Calgary residents caught what appeared to be a meteor streaking across the sky early on Wednesday morning.
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All 44 members of the B.C. Conservative caucus have been appointed to leadership positions – whether as shadow cabinet members or Opposition house leader.
The coach of a soccer team in the Vancouver Youth Soccer Association claims a complaint about racism directed at 13-year-old players on his team went unaddressed for more than a year.
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A Calgary family is warning others and wants to see more accountability for pet owners after their dog was attacked and seriously injured in the northwest community of Royal Oak.
The student union at the University of Ottawa says it will consider pulling its participation from the U-Pass, which provides discounted transit fares for students, if the city goes forward with hiking student transit fees and violating the program’s contract.
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A Regina chiropractor accused of sexually assaulting seven different women took the stand Thursday as arguments began in his defense.
Evraz North America says an investigation is underway after a contractor was fatally injured while on the job in Regina on Nov. 19.
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The City of Elliot Lake said Thursday it has received a $3-million donation from Edward and Suzanne Rogers for the Centennial Arena restoration.
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Posthumus played a stint with the London Lightning - hitting the court for 22 games in the 2015-2016 season, averaging 11 points, and 6.5 rebounds.
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The Crown played audio recordings in a Barrie courtroom Thursday afternoon that provided a glimpse into the lives of alleged human traffickers Lauriston and Amber Maloney and the group of young women who lived and worked for them.
Radon is the number one cause of lung cancer in non-smokers in Canada, according to Grey Bruce Public Health Unit.
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They’ve been based out of the basement of Hotel Dieu Grace Healthcare for many years, rent free - however, that partnership is coming to an end.
Windsor police are asking for the public’s help identifying a suspect wanted in connection to an alleged serious assault that happened this past summer.
Vancouver Island’s major crime unit is investigating the case of a Victoria teenager whose death was initially ruled an accidental overdose, but has since been reclassified by coroners as a homicide.
All 44 members of the B.C. Conservative caucus have been appointed to leadership positions – whether as shadow cabinet members or Opposition house leader.
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The Hurricanes launched a three-game road trip south of the border Wednesday dropping a 4-0 game to the league-best Everett Silvertips.
A new citywide campaign is hoping to encourage residents to shop, eat and explore local this holiday season.
Agriculture is an industry mainly dominated by men, but around 80 middle school and high school students – all of whom are female – are hoping to change that.
Sault-based charity Save Our Young Adults, or SOYA, will soon move to a new home -- for good reason.
The City of Elliot Lake said Thursday it has received a $3-million donation from Edward and Suzanne Rogers for the Centennial Arena restoration.
Students in Sault College’s business accounting program have a new learning pathway that will ultimately give them a head start to a career.
A Newfoundland energy company's embrace of data centres is raising doubts about eastern Canadian hopes of harnessing the region's howling winds to supply Germany with power from green hydrogen.
An international group led by a Canadian is in Rome this week to push the Catholic Church to adopt a zero-tolerance policy on abuse by clergy.
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