GRENFELL, Sask. - Four people have escaped a farmhouse fire in eastern Saskatchewan, but a six-year-old girl is missing and presumed dead.

RCMP say the house in the Grenfell district was fully engulfed in flames when fire departments arrived this morning.

The surviving family members have been transported to a hospital in Regina, about 100 kilometres to the west.

No names have been released.

It's the second fatal fire in two days in Saskatchewan.

Five people, including six-year-old twins, died in a blaze in Nipawin on Thursday.